The American Burn Association estimates that burn injuries claim the lives of at least 3,000 United States civilians and send another 500,000 to seek medical attention each year, of which 40,000 cases require hospitalization. Annual US expenditure on burn injuries is more than $2B in direct costs, with immeasurable indirect costs. Of burn patients admitted to hospitals, 10% have burns that exceed 30% of the Total Body Surface Area (TBSA). In addition, burns represent 5 to 20% of all combat related injuries; 20% of which are considered severe or involve more than 20% of TBSA. These burns result in significant morbidity and mortality, as well as long-term complications including functional impairment and aesthetic disfigurement.
Burns are dynamic injuries characterized by progressive extension of the size and severity (depth) of the burn over the course of several days. Burn progression is a well-known, but not completely understood phenomenon, with no FDA-approved preventative treatment.
Healing or Burn Progression
Burn Injury Progression
Leads to increased:
• healing time
Images from A.D.A.M.
Current treatments do not limit or prevent burn injury progression, speed healing of burn tissue or mitigate scarring.
Standard of Care
Prevent and/or treat infection
Dressings and Debridement
Surgical scar revision
NeoMatrix Potential Therapies
Our product candidates have the potential to limit burn injury progression to:
Speed wound closure
Reduce inflammation and scarring
Decrease costs of treatment and rehabilitation
Reduce disfigurement and disability
Restore patient to full employment or active duty